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Piccolo™
is a new, fully automated system for the
automated protein expresion and the rapid
optimisation of recombinant protein production
in microbial or insect cells. |
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The system has been designed
in conjunction with a consortium of 3 leading
global pharmaceutical companies and offers
the flexibility to vary and control a wide
range of protein culture parameters independently
and conduct experiments in parallel. |
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| Piccolo
automates: |
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- Automated protein expression
- Culture inoculation/infection
- Lysis
- Growth/induction
- Affinity purification
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| Piccolo
offers |
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- Significant reduction in protein production
timelines (from months to days)
- Improved run-to-run consistency and
site-to-site process transfer
- Provision of improved data for experimental
strategy design
- Focus on maintaining protein quality
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Piccolo enables
consistent and reliable determination of
the best construct, host strain, culture
conditions and induction/infection dynamics
for individual target proteins. It provides
the most comprehensive system for automated
protein expression. |
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- Structural biology
- Assay development
- Protein engineering
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Piccolo is currently
being used at 3 leading pharmaceutical companies
including Merck and GSK |
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GSK
chose Piccolo to support
their high throughput parallel expression
activities. |
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Piccolo
is designed to support to vary multiple
expression parameters rapidly in parallel
to enable automated protein expression to
be achieved in days rather than months,
These systems are a key tool in the expression
tool box to enhance availability of protein
early in the discovery cycle to enable determination
of structures and improve effectiveness
of lead optimisation |
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For
more information on Piccolo: |
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Get more
detail on automated
protein expression - key applications |
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Discuss
your requirements with Ian
Ransome, Sales Director |
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