Micro
bioreactor - ambr from TAP Biosystems
New advanced microscale bioreactor system for
cell line development
ambr™
mimics the characteristics of classical
bioreactors at microscale (10-15ml), by
using cost effective, disposable micro bioreactors,
controlled by an automated workstation.
ambr
enables the rapid evaluation of multiple
bioreactor cultures at microscale, increasing
productivity in cell line development with
significant savings on materials and labour.
The
new ambr micro bioreactor
in detail:
Central
to the system is the new
ambr micro bioreactor
– specifically designed
to mimic the characteristics
of a larger scale bioreactor.
To
learn more about the unique
design and key features
of the ambr micro
bioreactor - take an interactive
tour.
The ambr workstation controls
24 or 48 disposable micro bioreactors,
offering parallel processing and evaluation
of multiple experiments in an automated
microbioreactor benchtop system.
Closed loop control of pH and DO
with independent control of O2
and CO2 for each vessel
Automated liquid handling for reactor
set-up, feeds, base addition and sampling
Easy installation into laminar flow
hood allowing aseptic operation
A better tool for cell line selection
and development - closely mimics the
conditions of larger scale bioreactors)
Simplified adoption of Quality by
Design (QbD) principles for cell culture
development
Significant reduction in cost per
experiment
More experiments with less operator
time for set up and clean down
Applications
include:
Cell line selection
Cell line stability
Media feed strategies
Process robustness experimentation
in support of ‘quailty by design‘
studies
Automation of DOE approaches
to process optimisation
ambr
micro bioreactor system offers an accurate
and cost-effective approach to replicating
bioreactor conditions, and can be used as
a microscale model for a wide range of upstream
processes such as cell line selection and
process optimisation.
