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CellBase
CT is a new automated system designed
for ex-vivo expansion of autologous cell
therapy products. |
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Developed with leading cell
therapy organisations, CellBase CT scales
up existing manual cell culture processes
in T-flasks, enabling manufacture of cell
therapy products derived from a wide range
of cell types, including hES, iPS and adult
stem cells. |
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CellBase CT automates the
maintenance and expansion of cells in T-flasks
from multiple patients in a contamination-free,
aseptic environment. |
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- Maintains separation of individual
cell therapy products in T-flasks via
highly controlled processing including:
feeding, incubation, passage and harvest
- Uses automated microscopy to make
accurate measurements to trigger cell
harvesting at optimal cell confluency
- Includes precise counting and viability
measurement of cell suspensions prior
to seeding and for output
- Provides tracking via unique flask
bar codes and audit trail of all process
steps for each individual patient cell
therapy product
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CellBase CT is provided
with a range of tools to support validation
in GMP regulated laboratories. |
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CellBase CT offers a secure,
readily scalable alternative to labour intensive
manual cell culture for the manufacture
of cell therapy products. |
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- Provides aseptic processing environment
to protects cell therapy products from
contamination and cross-contamination
- Allows scale up of production to
support larger scale clinical trials
and manufacturing without process change
or need for regulatory re-approval
- Fully automated process using standard
T flasks allowing unattended operation
overnight and at weekends
- Consistent, high quality output of
cells of multiple individual patient
products in parallel from a single system
- Standardised solution to support
validation of the system for GMP regulated
production
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CellBase CT provides a restricted
access barrier system under negative pressure
to provide both protection of the operators
and an effective barrier to ensure aseptic
processing of the products. |
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- Process development to optimise cell
culture process and reduce cost of goods
- Production of clinical material to
support Phase II and Phase III trials
- Ex vivo expansion of cells for commercial
manufacture of autologous cell therapy
products
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For
more information on CellBase CT: |
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Get more
detail on the system's key application:
Cell
therapy |
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To discuss
your requirements please
contact the TAP team |
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